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KMID : 1134820110400020321
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Journal of the Korean Society of Food Science and Nutrition
2011 Volume.40 No. 2 p.321 ~ p.326
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Antihyperglycemic of Gleditschiae Spina Extracts in Streptozotocin - Nicotinamide Induced Type 2 Diabetic Rats
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Park Jae-Hee
Chu Won-Mi
Lee Jung-Min
Park Hae-Ryong
Park Eun-Ju
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Abstract
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The aim of the present study was to investigate antihyperglycemic effect of Gleditschiae Spina (GS) in streptozotocin (STZ)-nicotinamide (NA)-induced type 2 diabetic rats. The rats were divided into four groups: normal control (NC), diabetic control (DC), diabetic rats supplemented with acarbose (AC, 4 ㎎/㎏), and with GS ethanol extracts (GSE, 50 ㎎/㎏). Weekly fasting blood glucose (FBG) for 10 weeks and oral glucose tolerance test (OGTT) at 10th week were monitored using glucose oxidase-peroxidase reactive strips. The FBG level was significantly reduced in AC group after 8 weeks and in GSE group at the end of period. The AUCs for the glucose response from OGTT and blood glucose level after sacrifice were significantly lower in the AC and GSE groups than the DC group. GSE supplementation significantly increased plasma total radical-trapping antioxidant potential (TRAP) in STZ-NA-induced diabetic rats, compared with DC group. The present study indicates that GSE could ameliorate type 2 diabetes and be comparable to acarbose, a standard hypoglycemic drug. Also, we suggest that GSE may possess antioxidant activity against the STZ-NA-induced oxidative stress.
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KEYWORD
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Gleditschiae Spina, type 2 diabetes, streptozotocin, nicotinamide, OGTT, fasting blood glucose, TRAP
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